Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Osmidrosis lotion affect ApoD and ABCC11 mRNA levels in axillary osmidrosis patients

Bin Chen¹ , JiFeng Xie², KeKe Ding², ChunRong Gong²

¹Department of General Surgery, Huangpu Branch, ShangHai Nineth Peoples’ Hospital, Affiliated to ShangHai JiaoTong University, School of Medicine, China; ²Tianfang Yetan Medical Group, China.

For correspondence:- Bin Chen Email: sshchenbin@163.com

Accepted: 29 August 2023 Published: 30 September 2023

Citation: Chen B, Xie J, Ding K, Gong C. Osmidrosis lotion affect ApoD and ABCC11 mRNA levels in axillary osmidrosis patients. Trop J Pharm Res 2023; 22(9):1887-1891 doi: 10.4314/tjpr.v22i9.16

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the potential role of osmidrosis lotion in alleviating axillary osmidrosis (AO).

Methods: Forty patients were randomly divided into four groups (n = 10). Patients were treated via topical application of Lithargyrum, Sophora flavescens Alt., or Cortex dictamni, or osmidrosis lotion, for 40 min over a three-month period. Total skin RNA was extracted from samples using TRIzol while total platelet RNA was treated with DNase I, followed by quantification using NanoDrop and Agilent 2100 Bioanalyzer.

Results: Lithargyrum, Sophora flavescens Alt. and Cortex dictamni significantly inhibited the mRNA expressions of ApoD and ABCC11 in AO patients (p < 0.05). Furthermore, osmidrosis lotion produced the best down-regulating effect on mRNA expressions of ApoD and ABCC11 in AO patients.

Conclusion: The suppressive effect of these natural remedies may be beneficial in the development of non-surgical therapy for AO and therefore would be worth further investigation.

Keywords: Axillary osmidrosis, Treatment, Health promotion, Lithargyrum, Osmidrosis lotion